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KMID : 0360220080490111765
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Journal of the Korean Ophthalmological Society
2008 Volume.49 No. 11 p.1765 ~ p.1770
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The Changes of Aqueous Vasopermeability Factors After Intravitreal Triamcinolone Injection for Branch Retinal Vein Occlusion
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Song Seung
Park Sung-Pyo
Ahn Jae-Kyoun
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Abstract
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Purpose: To investigate the changes of aqueous vascular endothelial growth factor (VEGF) and interleukin (IL)-6 in patients with acute macular edema secondary to recent-onset branch retinal vein occlusion (BRVO) after a single intravitreal injection of triamcinolone acetonide (IVTA)
Methods: Aqueous and plasma levels of VEGF and IL-6 were measured by ELISA in ten controls and thirty patients at the time of IVTA and 3 months afterward. We compared the aqueous levels of VEGF and IL-6 and the clinical course between responders and non-responders.
Results: The aqueous levels of VEGF and IL-6 were significantly higher in non-responders than in responders at baseline measurements (495±259 pg/ml vs. 223±110 pg/ml, P<.001; 36±32 pg/ml vs. 16±19 pg/ml, P=.037, respectively). The aqueous levels of VEGF were still higher in non-responders (303±75 pg/ml) 3 months after IVTA, while the aqueous levels of VEGF in responders returned to normal (77±23 pg/ml, P<.001). The aqueous levels of IL-6 normalized in all patients 3 months after IVTA. In non-responders, central foveal thickness was significantly higher, and foveal ischemia and a wide non-perfused area were more common.
Conclusions: Non-IL6-dependent VEGF may contribute to persistent or recurrent ischemic macular edema associated with BRVO after IVTA. J Korean Ophthalmol Soc 2008;49(11):1765-1770
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KEYWORD
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Branch retinal vein occlusion, Interleukin-6, Intravitreal triamcinolone injection, Ischemic macular edema, Vascular endothelial growth factor
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